Flipping a Gene Switch Reactivates Fetal Hemaglobin, May Reverse Sickle Cell Disease
Science Daily (December, 2013) - Hematology researchers Jeremy W. Rupon, M.D., Ph.D., and Gerd Blobel, M.D., Ph.D of The Children's Hospital of Philadelphia have manipulated key biological events in adult blood cells to cause the cells to resume producing fetal hemoglobin, which is unaffected by the sickle cell disease mutation, and produce normally shaped red blood cells. http://www.sciencedaily.com/releases/2013/12/131208133646.htm
On the Cusp of a Cure - Sickle Cell Disease
Cornerstone, Children's Hospital of Philadelphia (September, 2013) - Dr. Alan Flake, MD, Center for Fetal Research at CHOP took part in the first open surgery involving the transplanting of stem cells from a mother’s bone marrow to her child. Clinical trials are expected for the next three years. The treatment has the potential to cure a broad range of related disorders, including thalassemias. http://www.research.chop.edu/blog/on-the-cusp-of-a-cure-sickle-cell-disease/
New Treatment for Sickle Cell Brings Hope, Cure
News Center, University of Illinois, Chicago (March, 2013) - The University of Illinois Hospital & Health Sciences System is the first to use an uncommon type of stem cell transplant performed without chemotherapy to cure two brothers of their sickle cell disease which resulted in their bone marrow producing healthy red blood cells. The efficacy and safety of the pre-transplant medication regimen are currently being studied at UI Health.http://news.uic.edu/new-treatment-for-sickle-cell-brings-hope-and-a-cure-to-chicago-area-patients#sthash.pjtfOULm.dpuf
Researchers Reveal Potential Treatment for Sickle Cell Disease
University of Michigan (November 2, 2011) - University of Michigan Health System study shows modulating protein expression can increase fetal hemoglobin in sickle cell patients
Using Math and Light to Detect Misshapen Red Blood Cells
ScienceDaily (October 31, 2011)
Researchers Correct Sickle Cell Disease in Adult Mice: Protein Could Be a Target for Treating People Who Have the Blood Disorder
ScienceDaily (October 13, 2011)
BUSM Researchers Awarded $9 Million to Ivestigate New Treatment for Sickle Cell Disease Using IPS Cells
Boston University (July 25, 2011)
Study Finds Nitric Oxide Does Not Help Sickle Cell Pain Crisis, National Institutes of Health, National Heart, Lung, and Blood Institute (March 2, 2011) Learn more about the trial: http://clinicaltrials.gov/ct2/show/NCT00094887
Two Studies Provide Insight Into Stroke Risk and Prevention in Young Sickle Cell Anemia Patients
ScienceDaily (Dec. 6, 2010) — Monthly blood transfusions combined with daily medication to remove the resulting excess iron remains the best approach for reducing the risk of recurrent strokes in young patients with sickle cell anemia, according to a preliminary analysis of a multicenter trial that includes St. Jude Children's Research Hospital.
Studies Investigate Pediatric Sickle Cell Disease and Potential Breakthrough in Controlling Malaria
ScienceDaily (Dec. 4, 2010) — Red blood cells (RBCs) have the very important role of carrying oxygen from the lungs to the rest of the body; therefore, disorders that affect RBCs can have a significant impact on quality of life. Sickle cell disease and malaria are two common RBC diseases that affect a significant portion of the U.S. and global populations. Sickle cell disease (SCD), a genetic blood disorder that causes deformed and dysfunctional red blood cells, affects an estimated 70,000 to 100,000 Americans, while malaria affects approximately 1,500 Americans annually and 190 to 311 million people worldwide. The red blood cells in sickle cell disease become rigid and form in a crescent "sickle" shape, which causes them to clump and become embedded in the blood vessels of organs, resulting in pain, infection, potential organ damage, and even death.
Successful Treatment for Mice With Beta-Thalassemia
ScienceDaily (Nov. 22, 2010) — Beta-thalassemia is an inherited blood disorder that results in chronic anemia. A major complication of the condition is iron overload, which damages organs such as the liver and heart. The iron overload has been linked to low levels of the protein hepcidin, a negative regulator of intestinal iron absorption and iron recycling.
New Sickle Cell Screening Program for College Athletes Comes With Serious Pitfalls, Experts Say
ScienceDaily (Sep. 21, 2010) — The Johns Hopkins Children's Center top pediatrician is urging a "rethink" of a new sickle cell screening program, calling it an enlightened but somewhat rushed step toward improving the health of young people who carry the sickle cell mutation.
Cannibinoids Offer Novel Treatment for Pain in Sickle Cell Disease, Study Suggests
ScienceDaily (July 23, 2010) — A University of Minnesota Medical School research team led by Kalpna Gupta, Ph.D., has discovered that cannibinoids offer a novel approach to ease the chronic and acute pain caused by sickle cell disease (SCD).
Trust Builds on Communication in Sickle Cell Disease (CME/CE)
By Kristina Fiore, Staff Writer, MedPage Today
Published: June 08, 2010
Reviewed by Dori F. Zaleznik, MD; Associate Clinical Professor of Medicine, Harvard Medical School, Boston and
Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner
Stroke Prevention Study in Children With Sickle Cell Anemia, Iron Overload Stopped Early
ScienceDaily (June 5, 2010) — The National Heart, Lung, and Blood Institute (NHLBI) has stopped a clinical trial evaluating a new approach to reduce the risk of recurrent stroke in children with sickle cell anemia and iron overload because of evidence that the new treatment was unlikely to prove better than the existing treatment.
Sickle Cell Disease May Affect Brain Function in Adults, Study Suggests
ScienceDaily (May 12, 2010) — Sickle cell disease may affect brain function in adults who have few or mild complications of the inherited blood disease, according to results of the first study to examine cognitive functioning in adults with sickle cell disease.
Low Blood Oxygen May Lead to Heart Defects in Children With Sickle Cell Disease
ScienceDaily (May 5, 2010) — Children with sickle cell disease who also have lower blood oxygen levels while both asleep and awake are likely to have heart abnormalities, researchers at Washington University School of Medicine in St. Louis and other institutions have found.
Vaccines Preventing Pneumococcal Disease Protect African Children With Sickle-Cell Disease
ScienceDaily (Apr. 28, 2010) — A new study in The Lancet Infectious Diseases finds that African children who contract pneumococcus -- a bacterial infection that causes pneumonia, meningitis and sepsis -- are 36 times as likely to have sickle-cell disease, a blood disorder prevalent in African children that increases the risk for infectious diseases and early death. The study underscores the critical need for use of pneumococcal conjugate vaccines (PCV) among populations predisposed to sickle-cell disease, most notably those in sub-saharan Africa.
Journal of Health Care for the Poor and Underserved
Volume 21, Number 1, February 2010
E-ISSN: 1548-6869 Print ISSN: 1049-2089
Carlton Haywood Jr.
Peter J. Fagan
Cynthia S. Rand
Examining the Effectiveness of Hydroxyurea in People with Sickle Cell Disease
Journal of Health Care for the Poor and Underserved - Volume 21, Number 1, February 2010, pp. 277-286
The Johns Hopkins University Press
Blood Stem-Cell Transplant Regimen Reverses Sickle Cell Disease in Adults
U.S. Department of Health and Human Services, National Institutes of Health
December 9, 2009
Screening To Help Prevent Stroke In Kids Increases, But Limited Access A Problem
ScienceDaily (Apr. 13, 2009) — The number of children with a certain blood disorder undergoing an ultrasound to help prevent stroke is up significantly in the past 10 years since the publication of a major study showing its benefits. However, limited access to labs that perform this type of screening appears to be a barrier to helping these children who are at a high risk of stroke.